ACL Top 350 CTS

Applications

Anticoagulant Therapy Monitoring: The ACL TOP 350 is frequently used to monitor patients on warfarin, heparin, and direct oral anticoagulants (DOACs), including the Anti-Xa assays used to monitor heparin therapy and Factor Xa inhibitors.

Hemostasis and Bleeding Disorder Testing: It is used for the diagnosis and management of various bleeding disorders, such as hemophilia, vitamin K deficiency, and liver disease. The analyzer's ability to measure fibrinogen levels, platelet function, and factor assays makes it suitable for a wide range of diagnostic needs.

Surgical and Preoperative Testing: The system is used in preoperative testing to assess bleeding risk before surgeries, especially for cardiac, neurological, and orthopedic surgeries.

Thrombophilia Screening: The ACL TOP 350 offers tests for thrombophilia (the tendency to develop abnormal clotting), which includes Factor V Leiden and prothrombin mutations.

Point-of-Care and Emergency Testing: The system is well-suited for high-pressure environments such as emergency departments (ED), ICUs, and trauma centers, where rapid coagulation testing is critical for patient management.

Technical Specifications:

Throughput: Up to 200 tests per hour.

Sample Types: Plasma, whole blood, serum.

Test Types: PT, APTT, Fibrinogen, D-dimer, Anti-Xa, Factor assays, Platelet function tests, Thrombophilia testing.

Reagents: Liquid reagents and reagent discs.

Sample Capacity: Sample carousel for continuous loading and up to 6 simultaneous tests.

Data Connectivity: Integration with LIS, HIS, and EMR systems for seamless data transfer.

Calibration and QC: Automatic calibration and built-in quality control features.

Display: Color touchscreen with graphical trend analysis and result interpretation.

Dimensions: Compact and space-efficient design, suitable for medium-volume labs.

Safety Features: Sample integrity checks and biohazard protection.

Product Description

The ACL TOP 350 is a high-performance coagulation analyzer developed by Werfen (formerly known as Instrumentation Laboratory). It is designed for medium to high-volume laboratories that require fast, accurate, and reliable testing of a wide range of hemostasis parameters, including blood coagulation profiles, platelet function, and specific assays for anticoagulation monitoring. The ACL TOP 350 is a member of the ACL TOP series, known for its advanced technology, flexibility, and efficiency in coagulation testing, making it suitable for a variety of clinical settings, from hospital laboratories to outpatient clinics. Key Features of the ACL TOP 350:

Key Features:

• Comprehensive Coagulation Testing Menu: The ACL TOP 350 offers a broad range of coagulation tests, including but not limited to:
  • Prothrombin Time (PT) and INR (International Normalized Ratio)
  • Activated Partial Thromboplastin Time (APTT)
  • Fibrinogen measurement
  • D-dimer assays
  • Thrombin Time (TT)
  • Anti-Xa assays for monitoring heparin therapy
  • Platelet function testing (e.g., platelet aggregation, ADP, and collagen)
  • Factor assays (e.g., Factor VIII, Factor IX, and others)
  The analyzer is capable of performing routine and specialized tests for hemostasis, allowing clinicians to evaluate bleeding and clotting disorders, as well as monitor anticoagulation therapy in patients.
• High Throughput and Rapid Turnaround Time:
  • The ACL TOP 350 is designed to handle medium to high test volumes, with a throughput of up to 200 tests per hour. This makes it suitable for high-demand environments such as hospitals, laboratories, and emergency departments where rapid results are required.
  • It offers a fast test turnaround time of typically less than 5 minutes per test, providing near-real-time results for critical care management.
• User-Friendly Interface:
  • The ACL TOP 350 features an intuitive touchscreen interface, which simplifies test setup, operation, and result interpretation.
  • The easy-to-read display shows test results clearly with color-coded values and graphical representations such as trend graphs and histograms for better visualization of patient data.
  • The system provides quick access to patient results, previous test history, and system settings.
• Advanced Quality Control and Calibration:
  • The ACL TOP 350 integrates automatic quality control (QC) to ensure accurate and reliable results. The system runs automated internal checks after every batch of tests and provides alerts if any QC parameters are out of range.
  • Automated calibration ensures consistent performance over time, reducing the need for manual intervention.
  • It also supports external quality control protocols, making it compliant with regulatory standards such as CAP (College of American Pathologists) and CLIA (Clinical Laboratory Improvement Amendments).
• Multiple Sample Types and Reagent Flexibility:
  • The ACL TOP 350 is compatible with various sample types, including plasma, whole blood, and serum, providing flexibility for different testing needs.
  • The system supports liquid reagents and reagent discs, offering convenience and flexibility for laboratories to manage inventory and optimize reagent use.
  • Reagents are designed for minimal waste, reducing overall operational costs.
• Automated Sample Loading and Processing:
  • The ACL TOP 350 features automated sample loading with a sample carousel that can hold a large number of samples, streamlining the workflow and improving overall efficiency.
  • The analyzer can process up to 6 samples simultaneously, increasing productivity in labs with high sample volumes.
• Data Management and Connectivity:
  • The ACL TOP 350 provides advanced data management features, including real-time data transfer to Laboratory Information Systems (LIS) and Hospital Information Systems (HIS).
  • Test results can be easily transmitted to electronic medical records (EMR) for integration into patient care workflows.
  • Trend analysis tools enable clinicians to track a patient's coagulation profile over time, which is especially valuable for managing patients on anticoagulant therapy or those with chronic bleeding disorders.
• Advanced Hemostasis Testing Capabilities:
  • The system offers specialized assays for thrombophilia screening, including testing for Factor V Leiden mutations, prothrombin gene mutations, and protein C and S deficiencies.
  • The ACL TOP 350 is ideal for comprehensive testing of patients with bleeding disorders (such as hemophilia and von Willebrand disease) as well as those at risk for thrombosis.
• Built-in Safety and Security Features:
  • The ACL TOP 350 incorporates sample integrity checks to ensure high-quality test results. The system checks for common sample-related issues like hemolysis, clotting, or inadequate sample volume before processing.
  • Biohazard protection features are built into the design, preventing contamination during sample handling and ensuring the safety of operators.