ACL TOP 750

Applications

Anticoagulant Therapy Monitoring:

• The ACL TOP 750 is essential for monitoring patients on anticoagulant therapy (e.g., warfarin, heparin, and DOACs). It performs tests like Anti-Xa assays to monitor heparin therapy and INR testing for patients on warfarin therapy, ensuring patients are within safe therapeutic ranges.

Bleeding Disorder Diagnosis:

• The analyzer is widely used for the diagnosis and management of bleeding disorders, such as hemophilia, von Willebrand disease, vitamin K deficiency, and liver disease. The system's ability to measure fibrinogen, platelet function, and factor deficiencies makes it an indispensable tool for hemostasis assessment.

Thrombophilia Screening:

• The ACL TOP 750 supports thrombophilia screening, including tests for Factor V Leiden mutations, prothrombin gene mutations, and deficiencies in Protein C and Protein S—all critical tests for diagnosing patients at risk of abnormal clotting.

Surgical and Preoperative Monitoring:

• The ACL TOP 750 is used in preoperative testing to assess coagulation status and ensure patients do not have abnormal bleeding or clotting risks before undergoing surgery.
• It is particularly useful in high-risk surgeries such as cardiac surgery, neurosurgery, and orthopedic procedures where blood loss and clotting can be significant concerns.

Critical Care and Emergency Medicine:

• In critical care settings such as ICUs and emergency departments, the ACL TOP 750 provides quick results for trauma patients, sepsis, and hemorrhagic shock, aiding clinicians in making fast, accurate decisions in life-threatening situations.

Technical Specifications:

Throughput: Up to 750 tests per hour.

Sample Types: Plasma, whole blood, serum.

Test Types: PT, APTT, INR, Fibrinogen, D-dimer, Anti-Xa, Factor assays, Platelet function tests, Thrombophilia screening.

Sample Capacity: Up to 40 samples simultaneously.

Reagents: Liquid reagents and reagent discs.

Display: Large, color touchscreen with graphical representations and trend analysis.

Data Connectivity: Integration with LIS, HIS, and EMR systems for real-time data transfer.

Quality Control: Automatic internal QC and external QC options.

Calibration: Automated calibration and self-checking.

Safety Features: Sample integrity checks, biohazard protection, automated system cleaning.

Dimensions: Compact design for high-throughput environments.

Product Description

The ACL TOP 750 is an advanced high-throughput coagulation analyzer designed by Werfen (formerly Instrumentation Laboratory) for large-volume laboratories requiring fast, accurate, and reliable coagulation testing. It is the most advanced model in the ACL TOP series, offering cutting-edge features for hemostasis testing, anticoagulant therapy monitoring, and bleeding disorder diagnostics. The ACL TOP 750 is engineered for maximum efficiency, automation, and precision, making it ideal for hospitals, reference laboratories, and clinical centers with high testing volumes and critical patient needs. This analyzer combines automated processing, fast result turnaround, and comprehensive test menus, allowing it to handle a wide range of coagulation assays while maintaining a high level of accuracy and reliability.

Key Features:

• Comprehensive Coagulation Testing Menu: The ACL TOP 750 offers an extensive test menu for a wide variety of hemostasis assays, including:
  • Prothrombin Time (PT) and INR (International Normalized Ratio)
  • Activated Partial Thromboplastin Time (APTT)
  • Fibrinogen levels
  • D-dimer assays
  • Thrombin Time (TT)
  • Anti-Xa assays for heparin monitoring
  • Factor assays (e.g., Factor VIII, Factor IX, Factor II)
  • Platelet function tests (e.g., platelet aggregation, platelet count)
  • Thrombophilia screening (Factor V Leiden mutation, prothrombin mutation, Protein C and S deficiencies)
  These tests are essential for monitoring anticoagulant therapy, diagnosing bleeding disorders and clothing disorders, assessing liver function, and evaluating thrombophilia in patients at risk for clotting.
• High Throughput and Rapid Test Results:
  • The ACL TOP 750 offers a high throughput, processing up to 750 tests per hour, making it ideal for large-volume laboratories with high demands for coagulation testing.
  • Rapid test turnaround times of less than 5 minutes per test ensure quick results for timely decision-making, especially in critical care, emergency medicine, and operating room settings.
• Automated Sample Handling and Continuous Loading:
  • The analyzer is equipped with automated sample loading, allowing labs to load and process up to 40 samples at a time without manual intervention.
  • It features a sample carousel that allows for continuous loading, meaning samples can be added while the analyzer is processing previous tests, increasing productivity and reducing delays in high-volume environments.
  • The system supports high-capacity testing, making it ideal for hospitals and reference labs with significant coagulation test demands.
• User-Friendly Interface:
  • The ACL TOP 750 features a large, intuitive touchscreen interface, making it easy to operate and navigate.
  • Results are displayed in clear, color-coded formats, with graphical representations like histograms and trend analysis for easier interpretation of coagulation profiles and test results.
  • The system is designed to minimize user error with simplified workflows and one-touch operations, enhancing laboratory efficiency and accuracy.
• Advanced Quality Control (QC) and Calibration:
  • The ACL TOP 750 comes with built-in automatic quality control to ensure accurate and reliable results for every test.
  • It performs internal quality checks after every batch of tests and provides real-time alerts if QC parameters are outside acceptable limits, ensuring high standards for result validity.
  • The system also features automated calibration, which helps maintain the precision and accuracy of test results over time, with minimal need for manual intervention.
• Multiple Sample Types and Flexible Reagents:
  • The ACL TOP 750 can process a variety of sample types, including plasma, whole blood, and serum, making it adaptable to different laboratory requirements
  • The analyzer is compatible with a wide range of reagents, including liquid reagents and reagent discs, offering flexibility in reagent management. This flexibility reduces costs and minimizes reagent waste, as well as enhances ease of use.
• Advanced Data Management and Connectivity:
  • The system integrates seamlessly with Laboratory Information Systems (LIS), Hospital Information Systems (HIS), and Electronic Medical Records (EMR), allowing for real-time data transfer and remote monitoring.
  • It supports trend analysis and the ability to track patient coagulation profiles over time, providing important insights into long-term changes in coagulation status.
  • Test results and patient data can be easily accessed, printed, or exported, facilitating quick and accurate reporting, and ensuring compliance with regulatory standards.
• Built-in Safety Features:
  • The ACL TOP 750 includes sample integrity checks to ensure high-quality test results. It checks for common issues like hemolysis, clotted samples, and insufficient sample volume before processing, ensuring only valid samples are tested.
  • The system is also equipped with biohazard protection and an automated cleaning mechanism, which minimizes the risk of cross-contamination and ensures safety for laboratory staff.
• Cost-Effective and Efficient Operation:
  • The ACL TOP 750 offers efficient reagent usage and automated maintenance routines to reduce operational costs.
  • The system is designed to provide long-term reliability with minimal maintenance, which helps laboratories reduce downtime and optimize resource utilization.